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課程資訊 |
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課程名稱 |
基礎生物感測器 Fundamentals of Biosensor Technology | |
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開課學期 |
109-2 | |
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授課對象 |
生物資源暨農學院 食品科技研究所 | |
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授課教師 |
貝格爾 | |
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課號 |
FOOD7313 | |
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課程識別碼 |
641 M3230 | |
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班次 |
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學分 |
2.0 | |
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全/半年 |
半年 | |
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必/選修 |
選修 | |
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上課時間 |
星期二6,7(13:20~15:10) | |
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上課地點 |
食研222 | |
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備註 |
總人數上限：30人 | |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 | |
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課程大綱
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課程概述 |
This course will provide an introduction into the most common biosensing principles with basic background information on the underlying theory as well as the current limitations of these technologies. The recent development in the field of biosensors is driven by creating robust and reliable devices for a vast variety of analytes while constantly improving the detection speed and the specificity particularly in food science and technology. Besides covering the sensing principle, the course will go into detail on fabrication aspects, stressing how microfabrication can be used to miniaturize these sensors. This course will give the detail on fabrication aspects, stressing how microfabrication can be used to miniaturize these sensors and their real world applications. | |
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課程目標 |
By the end of this course, the students will have:
1. A strong grasp of fundamentals of biosensor concept and designing, device fabrication, detection mechanism, electronic signal transduction and interpretation of collected data. 2. Knowledge in modeling biosensor interface with biological molecules and tissue interfaces. 3. An in-depth understanding of the impact of biological material and different nanomaterials on the performance of modern biosensors for food industry. 4. Ability of identifying appropriate biosensors for research and analytical applications for real food sample testing. | |
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課程要求 |
Biosensors are analytical tools or devices, integrated with a biological material such as enzymes, tissue, microorganisms, organelles, cell receptors, antibodies, nucleic acids, natural products etc. The biologically derived materials (e.g. recombinant antibodies, engineered proteins, aptamers, etc) or a biomimic (e.g. synthetic receptors, biomimetic catalysts, combinatorial ligands, imprinted polymers etc.) are also used within a physicochemical transducer. This microsystem technology provides a broad spectrum of application for the clinical analysis, environmental monitoring and food industry. | |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
1. Handbook of biosensors and biochips : Edited by Robert S. Marks ,
Edited by David C. Cullen , Edited by Isao Karube , Edited by Howard H. Weetall , Edited by Christopher Robin Lowe, John Wiley, Oxford, 2007. SBN13 9780470019054 2. “Biosensors Nanotechnology” Ashutosh Tiwari and Anthony P. F. Turner June 26, 2014, John Wiley & Sons | |
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評量方式 (僅供參考) |
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課程進度 |
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週次 |
日期 |
單元主題 |
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第1週 |
3/03 | Introduction to Biosensor-
Brief historical background Definition and working principle Components and bio-recognition elements Basic measuring procedures Characteristics of ideal biosensors and applications |
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第2週 |
3/10 | Biosensing element used in biosensors-
Biomolecules and support materials Types and properties and immobilization methods |
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第3週 |
3/18 | Analyte
Amperometric biosensors Generations of biosensors First generation Second generation Third generation |
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第4週 |
3/24 | Nanomaterials in biosensors-
The why of nanomaterials: Merits and demerits Influence on sensor performance |
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第5週 |
2020/03/31 | Bio-conjugation of nanomaterials-
Synthesis/ preparation, characterization and fabrication |
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第6週 |
4/07 | Nanomaterials: Physics of detection, fabrication and applications-
Nanoparticles, Nanotubes, nanowires, etc. |
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第7週 |
4/14 | Nano-biosensors Selectivity for environmental, food and pharmaceutical applications
Basis of molecular detection Evaluation of sensor performance, Static characteristics and real sample testing |
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第8週 |
4/21 | Potentiometric Sensors-
Theory of operation, Physics of detection, fabrication and applications |
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第9週 |
4/28 | Amperometric Sensors-
Theory of operation, physics of detection, fabrication and applications |
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第10週 |
5/05 | Mid-term Exam |
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第11週 |
5/12 | Electrochemical impedance spectroscopy (EIS) Based sensors
Theory of operation Physics of detection Fabrication and applications. |
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第12週 |
5/19 | Mass Based Sensors-
Theory of operation, physics of detection, fabrication and applications. |
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第13週 |
5/26 | Other sensors
(Microfluidic paper based assays) Designing of portable and fully integrated devices Lab-on Chip and Micro-array |
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第14週 |
6/02 | Biosensor applications in food industries I-
(i) Dairy industry- Pathogen/microorganism testing in milk, Test for preservation and pasteurization |
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第15週 |
6/09 | Biosensors in food quality-
(ii) Food processing and packaging Introduction, General applications, Detection of microorganisms, Quality control, Assure food safety Real time monitoring in food processing Analyte detection in food matrix (Fish, meat, sea food, etc.) Flow systems and flow injection analysis |
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第16週 |
6/16 | Biosensor applications in environmental monitoring (II)
Detection of heavy metals Bioactive genotoxic analytes, Residual agrochemicals, bioremediation Water pollution-Detection of non-permitted and toxic chemicals |
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第17週 |
06/23 | Biosensor applications in health care and life science research (III)
Biosensors for point of care application- Diabetic management, cardiovascular diseases, cancer and other clinical applications |
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第18週 |
06/30 | Final Exam |